Age Reversal in a pill is a reality now.

LIGHTNING RELEASES: Arlington, Virginia, Biotivia (1/6/2014) – Biotivia scientists, and our colleagues at Harvard Medical School, are confident that MitoTrans®* (NAD+) is the most important discovery to date in the reversal of cell aging. 

This natural enzyme has been shown to dramatically reverse a fundamental aspect of age-related deterioration in the energy producing mitochondria of animal cells.  MitoTrans® was shown to transform the mitochondria of late life animals to the age equivalent of young, healthy, fit animals. This long sought achievement has never been realized before.

In the December 2013 trial undertaken by David Sinclair and his fellow scientists at Harvard University – working in collaboration with New South Wales University of Sydney Australia, and the National Institutes of Health’s National Institute on Aging – the researcher team reported: “The aging process we discovered is like a married couple: when they are young, they communicate well but over time, living in close quarters for many years, communication breaks down,” said Professor David Sinclair, who is based at Harvard Medical School. “And just like a couple, restoring communication solved the problem.” 

Sinclair, who also discovered the Sirt activation properties of Resveratrol, stated: “We have two major chromosome sets in our body –  the chromosomes that we all know about, we call it our genome. But there’s other DNA that we often don’t think about – the mitochondrial DNA that we get from our mothers.” Professor Sinclair continued: “During ageing these two genomes don’t talk to each other. We found that we could reverse that and get the communication going again and the animals went back to being young again.”  To characterize this development as revolutionary in the field of longevity medicine is not an exaggeration. It’s implications reach far beyond simple cell aging.

The study,  published in the December 13 edition of the prestigious journal Cell (1), reported that administration of a compound known as nicotinamide adenine dinucleotide, or NAD+, rolled back the clock to day one on muscle tissue exposed to the compound. NAD+ is one of the enzymes that all of our cells produce, but which diminishes with age. The evil twin enzyme of NAD+ is NADH.  NADH counters the actions of NAD+, and increases in proportion to NAD+ as one ages. The result is the gradual loss of the muscle quality, strength, flexibility and function which we enjoy in our youth.  Although the researchers stated that the sooner one begins taking MitoTrans® the greater the results one can expect, even animals near the end of their natural lifespan responded with the improvement equivalent to taking a 60-year-old human muscle back to the condition of a fit 20-year-old. No other compound or pharmaceutical has been able to accomplish this before.

Dr Nigel Turner, senior research fellow at UNSW and co-author of the study, in an interview with The Guardian paper (2) stated: “The rate of age reversal in mice was “amazingly rapid”. 

Turner went on to say that: “A ‘magic pill’ that reverses aging is several years away, partially due to the cost of the compound, which would be about $50,000 a day for a human.”  Biotivia has moved Dr. Turner’s estimate several years ahead, just as we did with both Resveratrol and Pterostilbene. We have also brought the cost down to a fraction of the amount referred to by Dr Turner. Althought not a trivial amount, the cost for a treatment, including a complimentary sustained release Trans-resveratrol adjutant is affordable for most consumers.  NAD+ and trans-resveratrol are interdependent with respect to activation of the anti-aging gene Sirt 2 in humans.

NAD+ is a genuine breakthrough in the battle against aging.  

Biotivia scientists have been keenly aware of the potential of this unique molecule – particularly its chemo-preventative properties and its applications to human health and health span – for more than 5 years. We have been working with our pharmaceutical partners to make it available to enlightened consumers at an affordable cost.  

Over the past year we have succeeded in developing the technology to produce highly purified NAD+ in limited commercial quantities at a fraction of the cost Dr. Turner alluded to in his recent interviews with the Guardian, the BBC, and several other news channels.  

Biotivia Labs, the first nutraceutical research and development company to offer pharma grade Trans-resveratrol, and the first company to create a high potency Pterostilbene supplement, is now the first company in the world to offer a certified pharmaceutical grade NAD+ sustained release supplement to the public.  The cost of this supplement is not trivial, however it is nowhere near the $50,000 per day estimate of Dr Turner. Biotivia is offering a one time, 30-day treatment regimen which, based on the mass of scientific evidence from multiple studies, should be sufficient for the average person to achieve the mitochondrial reversal effect seen in the recent animal study.  One treatment semi-annually should be adequate to sustain the improvement indefinitely. 

Clearly, there is more to the aging process than mitochondrial deterioration, and Biotivia does not claim that this is the entire answer to the challenge of increasing health span. However we do believe that it is the most important development to date, and MitoTrans® appears to be one critical, quantum leap ahead in achieving the goal of optimum quality of life and health span. NAD+ has potential health properties that go beyond cell age reversal. Studies have revealed important potential cancer, Diabetes, Alzheimer’s Disease, and Cardiovascular applications for this molecule. 

Biotivia produced compounds are the choice of many medical schools and research organisation for use in their human clinical trials. The company has collaborated with some of the world’s leading universities on clinical trials and the development of advanced chemo-preventative agents derived from naturally occurring plant based molecules. 

People interested in knowing more about MitoTrans should email info@biotivia.com

Important Notes for editors:

Note 1. This molecule is extremely complex and difficult to produce in the particular form and quality used in the Harvard trial. Many suppliers offer a molecule that they represent to be NAD+ which is actually NADH, its biological opposite.   No other supplier is offering a compound equivalent to Mito Trans. Bear in mind that NAD and NADH have not been shown to have any life extension of confirmed health benefits. In fact, the evidence points to the contrary conclusion.  The NAD+/NADH ratio is the critical value to be aware of. Adding NADH to one’s diet actually worsens this ratio. Only by adding NAD+ is the ratio enhanced, as it was in the Harvard study.  

Note 2.  NAD+ does not survive passage through the stomach unless protected by advanced sustained-release technology.  Simply consuming NAD+ without this protection is not effective.  MitoTrans® is produced using the same sustained release technology Biotivia utilizes to protect Transmax TR from deterioration by gastric acids and enzymes. 

Regulatory note. MitoTrans® is the Biotivia trademark for its proprietary, purified, pharmaceutical grade NAD+ supplement manufactured using a sustained release technology which prevents destruction of the molecule by gastric fluids. The scientific name for MitoTrans® is nicotinamide adenine dinucleotide.  MitoTrans® is not meant to prevent, diagnose, treat or cure any disease, nor does Biotivia make any specific health claims for this supplement. 

Links referred to this in article:

1: https://www.cell.com/abstract/S0092-8674(13)01521-3
2:http://www.theguardian.com/science/2013/dec/20/anti-ageing-human-trials

Scientific References

NAD+ and Diabetes:
http://www.diabetes.co.uk/news/2013/Dec/chemical-found-to-reverse-insulin-resistance-and-ageing-93001809.html

NAD+ and Alzheimer’s Disease:
http://link.springer.com/article/10.1007/BF03033501

NAD+ and Cancer:
http://mct.aacrjournals.org/content/8/11/3130.short

NAD+ and Cardiovascular disease:
http://www.ingentaconnect.com/content/ben/cpd/2009/00000015/00000001/art00011

Contact for more information:

Cristina Sebastian
Biotivia LLC
2503 D N. Harrison St.
Ste. 13
Arlington, Virginia VA 22207

www.biotivia.com
email: info@biotivia.com

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